MM-S was on average lower than Riley shunt (− 0.05 ± 0.10), with lower and upper limits of agreement of − 0.15 and 0.04, respectively. We compared MMIMS-derived shunt (MM-S) to Riley shunt, and MMIMS-derived dead space (MM-VD) to Bohr dead space in 349 data pairs. The samples were injected into the MMIMS, and resultant retention and excretion data were translated to VA/Q distributions. Inert gas infusion (saline mixture of SF6, krypton, desflurane, enflurane, diethyl ether, acetone) was maintained, and after induction of lung damage, blood and breath samples were taken at 15-min intervals over 4 h. Thirty anesthetized pigs were randomly assigned to lavage or pulmonary embolism groups. We aimed at comparing shunt fractions and dead space derived from MMIMS–MIGET with Riley shunt and Bohr dead space, respectively. MIGET-when performed using Micropore Membrane Inlet Mass Spectrometry (MMIMS)-has been proven to correlate well with GC-MIGET and reduces analysis time substantially. The multiple inert gas elimination technique (MIGET) using gas chromatography (GC) is an established but time-consuming method of determining ventilation/perfusion (VA/Q) distributions.
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